反应详情

To a solution of ethyl 4-oxocyclohexanecarboxylate (22.75 g) and pyrocatechol (14.75 g) in toluene (200 mL) was added catalytic amount of para-toluenesulfonic acid monohydrate and the mixture was stirred under reflux and a Dean-Stark trap overnight. The mixture was diluted with diethyl ether (600 mL) and washed with aqueous NaHCO3, water and brine. After drying over Na2SO4, the mixture was filtered and the solvent was evaporated under vacuum to provide the title compound.

1. temperatureunder reflux
2. customa Dean-Stark trap overnight
3. washwashed with aqueous NaHCO3, water and brine
4. dry with materialAfter drying over Na2SO4
5. filtrationthe mixture was filtered
6. customthe solvent was evaporated under vacuum