反应详情

To a mixture of triethylsilane (9.95 g, 85.78 mmol) in TFA (25 mL) was added portionwise methyl oxo(1H-pyrrolo[2,3-b]pyridin-3-yl)acetate (5.0 g, 24.48 mmol). After a period of 18 h at 50° C., the solvent was evaporated and saturated NaHCO3 was added followed by DCM. The organic phase was separated, dried over magnesium sulfate, filtered and evaporated under reduced pressure. The residue was purified by combiflash with 10% ethyl acetate in hexane to 100% ethyl acetate to provide 3.5 g of the title compound.

1. customthe solvent was evaporated
2. additionsaturated NaHCO3 was added
3. customThe organic phase was separated
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customThe residue was purified by combiflash with 10% ethyl acetate in hexane to 100% ethyl acetate