Hydrochloric Acid → HCID 71060422, compound

HRID 1036728Notes

Reaction equation

HRID 1036728 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH:5]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:4][N:3]1[CH2:25][C:26]([F:29])([F:28])[F:27].[ClH:30].O1CCOCC1>C(Cl)Cl>[ClH:30].[C:19]1([CH:5]2[C:6]3([CH2:11][CH2:10][CH2:9][NH:8][CH2:7]3)[C:2](=[O:1])[N:3]([CH2:25][C:26]([F:28])([F:29])[F:27])[CH2:4]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71060151HCID 71060151, compound

Product 1

HCID 71060422HCID 71060422, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 1-oxo-4-phenyl-2-(2,2,2-trifluoroethyl)-2,7-diazaspiro[4.5]decane-7-carboxylate (0.874 g, 2.119 mmol) in DCM (10 ml) was treated with 4M HCl in 1,4-dioxane (4.5 ml, 0.018 mmol). The reaction mixture was stirred at room temperature for 9 hours. The solvent was removed in vacuo to give the title compound.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-feb523d4a1c549eea3a829857bb2f85b
Source dataset
uspto-grants-2013_10
Patent number
US08546416B2

Reaction notes

Loading…