反应详情

A stirred solution of rac-tert-butyl 1-oxo-3-phenyl-2,6-diazaspiro[3.5]nonane-6-carboxylate (1.18 g, 3.73 mmol) in DMF (20 ml) was cooled to 0° C. and treated with NaH (194 mg, 4.85 mmol) followed by iodomethane (303 ul, 4.85 mmol). The mixture was left to warm to room temperature. After 5 hours, the reaction was quenched with water and extracted with ethyl acetate. The organic layer was separated and washed with brine, dried (MgSO4) and concentrated in vacuo to yield a the title compound as a yellow oil;

1. waitThe mixture was left
2. customthe reaction was quenched with water
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo