反应详情

温度

100 °C

Under argon, 61.0 mg (0.16 mmol) of the compound from Example 24A are provided in 3 ml of 1,2-dimethoxyethane, and 26.1 mg (0.16 mmol) of 3-cyano-4-fluorophenylboronic acid, 155 mg (0.47 mmol) of cesium carbonate, 5.3 mg (0.01 mmol) of dicyclohexyl[2′,4′,6′-tri(propan-2-yl)biphenyl-2-yl]phosphane and 1.1 mg (0.005 mmol) of palladium(II) acetate are added. The mixture is heated in a closed glass vessel at 100° C. under microwave irradiation for 30 minutes. The reaction mixture is purified by preparative HPLC (RP18 column; eluent: acetonitrile/water gradient). 23.0 mg (34% of theory) of the title compound are obtained.

1. customThe reaction mixture is purified by preparative HPLC (RP18 column; eluent: acetonitrile/water gradient)