2,4,5-Trimethoxybenzaldehyde → HCID 67067673, compound

HRID 1037190Notes

Reaction equation

HRID 1037190 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5](OC)=[C:6]([CH:8](O)[C:9]#CC2C=CC=CC=2)[CH:7]=1.[CH3:20][O:21][C:22]1[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[CH:26][C:23]=1[CH:24]=[O:25]>>[C:6]1([C:8]#[C:9][CH:24]([C:23]2[CH:26]=[C:27]([O:32][CH3:33])[C:28]([O:30][CH3:31])=[CH:29][C:22]=2[O:21][CH3:20])[OH:25])[CH:7]=[CH:2][CH:3]=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 205252,4,5-TrimethoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 67067673HCID 67067673, compoundYield 90%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2,4,5-trimethoxybenzaldehyde was reacted to give the title compound as an off-white solid (535 mg, 90%). LCMS (Method B): RT=3.99 min, [M+Na]+=321.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-55e1d4fad0dd46bbaae5370dfe3552e4
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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