2,3-Dimethoxybenzaldehyde → HCID 67067745, compound

HRID 1037193Notes

Reaction equation

HRID 1037193 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.[CH3:20][O:21]C1C(OC)=CC=CC=1C=O>>[C:11]1([C:10]#[C:9][CH:8]([C:6]2[CH:7]=[CH:2][CH:3]=[C:4]([O:21][CH3:20])[C:5]=2[O:18][CH3:19])[OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 665812,3-DimethoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 67067745HCID 67067745, compoundYield 66%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2,3-dimethoxybenzaldehyde was reacted to give the title compound as a colourless oil (352 mg, 66%). LCMS (Method B): RT=4.09 min, [M+Na]+=291.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-f55ee837c029486e84fd6d38624c310d
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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