反应详情

温度

17.5 °C

30 kg of DL-Methionine was added to a solution of methane sulphonic acid (390 kg) maintained at 15-20° C. and stirred for 30 minutes. To this solution, 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one (40 kg) was added at 20° C. and the reaction mass was heated to 50-55° C. the reaction mixture was maintained at 50-55° C. for 12.0 hrs. After reaction completion, it was quenched in a mixture of methanol (400 L) and water (800 L) and the pH of the resultant solution was adjusted to 9-9.2 with aqueous ammonia at below 20° C. The product was extracted with methylene dichloride and concentrated to obtain the product which was isolated with cyclohexane. Yield: 33.4 kg

1. temperaturethe reaction mass was heated to 50-55° C. the reaction mixture
2. temperaturewas maintained at 50-55° C. for 12.0 hrs
3. customAfter reaction completion, it
4. customwas quenched in a mixture of methanol (400 L) and water (800 L)
5. customwas adjusted to 9-9.2 with aqueous ammonia at below 20° C
6. extractionThe product was extracted with methylene dichloride
7. concentrationconcentrated
8. customto obtain the product which