Triethoxysilane → HCID 86664259, compound

HRID 1037697Notes

Reaction equation

HRID 1037697 reaction equation
[CH2:1]([O:5][CH:6]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]#[C:7]1)[CH2:2][CH:3]=[CH2:4].[CH2:14]([O:16][SiH:17]([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])[CH3:15]>>[CH:6]1([O:5][CH2:1][CH2:2][CH2:3][CH2:4][Si:17]([O:21][CH2:22][CH3:23])([O:18][CH2:19][CH3:20])[O:16][CH2:14][CH3:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:8]#[C:7]1

Participants

3

Reactant 2

HCID 13830TriethoxysilaneHCID 866642583-(But-3-enyloxy)cyclooct-1-yne

Product 1

HCID 86664259HCID 86664259, compoundYield 97%

Procedure

The compound 3 (1.28 g, 7.18 mmol) is mixed with triethoxysilane (3.6 ml). The Karstedt catalyst is added very slowly in a catalytic amount (10 drops). The reaction takes place at 45° C. over three days. The product is purified by flash chromatography (100% AcOEt) to give a brown liquid (2.4 g, 7 mmol, 97%).

Workup

  1. customat 45° C.
  2. customover three days
  3. customThe product is purified by flash chromatography (100% AcOEt)

Sources & evidence

ORD record
ord-b7d28a078aaf403dac6402008201e627
Source dataset
uspto-grants-2013_10
Patent number
US08546598B2

Reaction notes

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