Trifluoroacetic acid → 4-(Phenylethynyl)piperidine

HRID 1038042Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[C:16]1([C:15]#[C:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 17986993N-BOC-4-(phenylethynyl)piperidine

Product 1

HCID 179869654-(Phenylethynyl)piperidine

Procedure

4-Phenylethynyl-piperidine-1-carboxylic acid tert-butyl ester was treated with TFA for 10 minutes and concentrated, lyophilized to provide the title product.

Workup

concentrationconcentrated

Sources & evidence

ORD record: ord-0e507e666e7f493f85b4c3610235c6ba
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546404B2

Reaction notes

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