Cesium carbonate → HCID 86614439, compound

HRID 1038080Notes

Reaction equation

HRID 1038080 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].[F:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([NH:23][C:24]([C:26]4([CH:31]([OH:33])[CH3:32])[CH2:30][CH2:29][NH:28][CH2:27]4)=[O:25])[CH:21]=3)[N:16]([C:34]([C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[N:15]=2)=[CH:10][CH:9]=1.Cl[CH2:54][C:55]([N:57]1[CH2:62][CH2:61][N:60]([C:63]2[CH:68]=[CH:67][C:66]([C:69]3[N:74]=[CH:73][CH:72]=[CH:71][N:70]=3)=[CH:65][CH:64]=2)[CH2:59][CH2:58]1)=[O:56]>CN(C=O)C>[F:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([NH:23][C:24]([C:26]4([CH:31]([OH:33])[CH3:32])[CH2:30][CH2:29][N:28]([CH2:54][C:55](=[O:56])[N:57]5[CH2:62][CH2:61][N:60]([C:63]6[CH:64]=[CH:65][C:66]([C:69]7[N:70]=[CH:71][CH:72]=[CH:73][N:74]=7)=[CH:67][CH:68]=6)[CH2:59][CH2:58]5)[CH2:27]4)=[O:25])[CH:21]=3)[N:16]([C:34]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[C:47]3[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=3)[N:15]=2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 58946437HCID 58946437, compoundHCID 86614438HCID 86614438, compound

Product 1

HCID 86614439HCID 86614439, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Added Cesium carbonate (60 mg, 0.184 mmol) to a solution of 3-(1-Hydroxy-ethyl)-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1Trityl-indazol-5-yl]-amide (6N) (60 mg, 0.098 mmol) and 2-chloro-1-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethanone (50 mg, 0.158 mmol) in DMF (2 ml) at room temperature, then stirred overnight.

Sources & evidence

ORD record
ord-ec3ea0937fb244ceb47f834f19344d45
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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