Diisopropylethylamine → HCID 86630174, compound

HRID 1038108Notes

Reaction equation

HRID 1038108 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18]([C:20]4([S:25][CH3:26])[CH2:24][CH2:23][NH:22][CH2:21]4)=[O:19])[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl[CH2:28][C:29]([N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:42]=[CH:41][C:40]([C:43]3[N:48]=[CH:47][CH:46]=[CH:45][N:44]=3)=[C:39]([F:49])[CH:38]=2)[CH2:33][CH2:32]1)=[O:30].C(N(C(C)C)CC)(C)C>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18]([C:20]4([S:25][CH3:26])[CH2:24][CH2:23][N:22]([CH2:28][C:29]([N:31]5[CH2:36][CH2:35][N:34]([C:37]6[CH:42]=[CH:41][C:40]([C:43]7[N:44]=[CH:45][CH:46]=[CH:47][N:48]=7)=[C:39]([F:49])[CH:38]=6)[CH2:33][CH2:32]5)=[O:30])[CH2:21]4)=[O:19])[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 57686143HCID 57686143, compoundHCID 86630175HCID 86630175, compound

Product 1

HCID 86630174HCID 86630174, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Methylsulfanyl-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide (12AB) (40 mg, 0.09 mmol, 1 equiv) and 2-Chloro-1-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethanone (7AB) (37 mg, 0.11 mmol, 1.2 equiv) were weighed out in a flask, and to it was added N,N-dimethylformamide (3 mL) and diisopropylethylamine (23 mg, 32 uL, 0.18 mmol, 2 equiv). The reaction content was stirred at room temperature overnight.

Sources & evidence

ORD record
ord-b2fb18707690443b894bd49821b25f9a
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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