Sodium Iodide → HCID 71046973, compound

HRID 1038113Notes

Reaction equation

HRID 1038113 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18]([CH:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)=[O:19])[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl[CH2:26][C:27]([N:29]1[CH2:34][CH:33]=[C:32]([C:35]2[CH:40]=[CH:39][C:38]([C:41]3[N:46]=[CH:45][C:44]([F:47])=[CH:43][N:42]=3)=[C:37]([F:48])[CH:36]=2)[CH2:31][CH2:30]1)=[O:28].C(=O)(O)[O-].[K+].[I-].[Na+]>C(#N)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18]([CH:20]4[CH2:24][CH2:23][N:22]([CH2:26][C:27]([N:29]5[CH2:30][CH:31]=[C:32]([C:35]6[CH:40]=[CH:39][C:38]([C:41]7[N:42]=[CH:43][C:44]([F:47])=[CH:45][N:46]=7)=[C:37]([F:48])[CH:36]=6)[CH2:33][CH2:34]5)=[O:28])[CH2:21]4)=[O:19])[CH:15]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 516893Potassium BicarbonateHCID 57686028HCID 57686028, compoundHCID 86630176HCID 86630176, compound

Product 1

HCID 71046973HCID 71046973, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide (24AB) (30 mg, 0.093 mmol, 1 equiv), 2-Chloro-1-{4-[3-fluoro-4-(5-fluoro-pyrimidin-2-yl)-phenyl]-3,6-dihydro-2H-pyridin-1-yl}-ethanone (23AB) (36 mg, 0.102 mmol, 1.1 equiv), potassium bicarbonate (47 mg, 0.465 mmol, 5 equiv), and sodium iodide (3 mg, 0.019 mmol, 0.2 equiv) were all weighed out in a flask and to it was added acetonitrile (3 mL). The reaction content was stirred at room temperature overnight.

Workup

  1. customall weighed out in a flask and to it

Sources & evidence

ORD record
ord-c61192dd617041f7b607eb4824f21669
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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