2,4-Difluoroaniline → N4-(2,4-difluorophenyl)-N6-methylpyrimidine-4,6-diamine

HRID 1038693Notes

Reaction equation

HRID 1038693 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH3:9])[CH:3]=1.[F:10][C:11]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=1[NH2:13]>>[F:10][C:11]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:12]=1[NH:13][C:2]1[CH:3]=[C:4]([NH:8][CH3:9])[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 97092,4-DifluoroanilineHCID 3094796-chloro-N-methylpyrimidin-4-amine

Product 1

HCID 66669984N4-(2,4-difluorophenyl)-N6-methylpyrimidine-4,6-diamine

Procedure

The title compound is prepared analogously as described in Example 114A from (6-chloro-pyrimidin-4-yl)-methylamine and 2,4-difluoroaniline.

Sources & evidence

ORD record
ord-94719721919f41d890733362b8096c15
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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