Methylamine → 4-Chloro-N-methyl-1,3,5-triazin-2-amine

HRID 1038742Notes

Reaction equation

HRID 1038742 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[CH3:9][NH2:10]>C1COCC1.O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:10][CH3:9])[N:7]=1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 178102,4-Dichloro-1,3,5-triazine

Product 1

HCID 179596504-Chloro-N-methyl-1,3,5-triazin-2-amine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To an ice cooled solution of 2,4-dichlor-[1,3,5]triazine (2.25 g, 15 mmol; WO 2004/072063, Expl. 9) in 20 ml of THF, MeNH2 (15 ml of 2 M solution in THF) is added. After 1 h the mixture is diluted with 15 ml of water and concentrated partially in vacuo. The precipitated title compound can be filtered off, washed with ice-water and dried: ESI-MS: 143 [M−H.

Workup

  1. concentrationconcentrated partially in vacuo
  2. customThe precipitated title compound
  3. filtrationcan be filtered off
  4. washwashed with ice-water
  5. customdried

Sources & evidence

ORD record
ord-aaf47c52ecdb4d829dce2ef357e406e5
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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