HRID1038846
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
A mixture of K2CO3 (0.052 g, 0.38 mmol), Pd2dba3 (0.017 g, 0.019 mmol), 3-methyl-1H-indazol-6-amine (0.028 g, 0.19 mmol, Advanced ChemBlocks), 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)piperidine-4-carbonitrile (0.050 g, 0.19 mmol) and X-phos (0.018 g, 0.038 mmol) in 1,4-dioxane (10 mL) was stirred at about 100° C. for about 12 h. The solvent was removed and the residue was purified by Prep-TLC (DCM/MeOH 20:1) to give 1-(2-(3-methyl-1H-indazol-6-ylamino)furo[3,2-d]pyrimidin-4-yl)piperidine-4-carbonitrile (0.020 g, 28%): LC/MS (Table 2, Method 1) Rt=0.63 min; MS m/z: 374 (M+H)+.
WORKUP
后处理
- customThe solvent was removed
- customthe residue was purified by Prep-TLC (DCM/MeOH 20:1)