反应详情

2-{4-[(1S,2S)-2-(2-azidoethyl)cyclopropyl]piperidin-1-yl}-5-chloropyrimidine (34 mg, 0.11 mmol) from step 2 of this example was dissolved in THF (1 mL), triphenylphosphine (58.1 mg, 0.22 mmol) was added, then water (0.085 mL). The reaction was run at room temperature for 1 hour, then 40° C. 1 hour. The reaction was cooled down to room temperature, concentrated to dryness and purified by column chromatography through a 12 gram RediSep Rf™ silica gel cartridge eluting with 10% methanol/dichloromethane to give the title compound as a white solid.

1. custom40° C
2. custom1 hour
3. concentrationconcentrated to dryness
4. custompurified by column chromatography through a 12 gram RediSep Rf™ silica gel cartridge
5. washeluting with 10% methanol/dichloromethane