反应详情

A solution of 1-(tert-butoxycarbonyl)piperazine (1.38 g, 7.41 mmol) in acetonitrile (10 mL) was stirred with triethylamine (2.07 mL, 14.8 mmol) and methyl 2-bromoacetate (1.02 mL, 11.1 mmol) at room temperature for 4 hours and then filtered. The filtrate was concentrated, and after addition of saturated aqueous ammonium chloride, extracted with ethyl acetate. The organic phase was washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the desired product (yield 83%).

1. filtrationfiltered
2. concentrationThe filtrate was concentrated
3. additionafter addition of saturated aqueous ammonium chloride
4. extractionextracted with ethyl acetate
5. washThe organic phase was washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated