Dimethylformamide → 5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((5-fluoro-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

HRID 103914Notes

Reaction equation

HRID 103914 reaction equation
[CH2:1]([CH3:2])[N:3]([c:4]1[c:5]([CH3:26])[c:6]([C:7](=[O:8])[OH:9])[cH:10][c:11](-[c:13]2[cH:14][cH:15][c:16]([CH2:19][N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[cH:17][cH:18]2)[cH:12]1)[CH:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1.[CH:57]([N:58]([CH2:59][CH3:60])[CH:61]([CH3:62])[CH3:63])([CH3:64])[CH3:65].[NH2:66][CH2:67][c:68]1[c:69](=[O:77])[nH:70][c:71]([CH3:76])[c:72]([F:75])[c:73]1[CH3:74].[O:78]=[CH:79][N:80]([CH3:81])[CH3:82].[P-:33]([F:34])([F:35])([F:36])([F:37])([F:38])[F:39].[n:40]1([O:41][C:42]([N:43]([CH3:44])[CH3:45])=[N+:46]([CH3:47])[CH3:48])[c:49]2[n:50][cH:51][cH:52][cH:53][c:54]2[n:55][n:56]1>>[CH2:1]([CH3:2])[N:3]([c:4]1[c:5]([CH3:26])[c:6]([C:7](=[O:9])[NH:66][CH2:67][c:68]2[c:69](=[O:77])[nH:70][c:71]([CH3:76])[c:72]([F:75])[c:73]2[CH3:74])[cH:10][c:11](-[c:13]2[cH:14][cH:15][c:16]([CH2:19][N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[cH:17][cH:18]2)[cH:12]1)[CH:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 671242643-(Aminomethyl)-5-fluoro-4,6-dimethyl-2(1H)-pyridinoneHCID 708725843-[Ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzoic acid

Product 1

HCID 708728505-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((5-fluoro-4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide

Sources & evidence

ORD record
ord-5b26efaed8614c65bb3208eb76e2fadd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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