反应详情

Add triethylamine (5.6 mL, 40 mmol) to a solution of 7-ethoxycarbonimidoylheptanoic acid ethyl ester (11.0 g, 41 mmol) and benzoic acid hydrazide (5.5 g, 40 mmol) in ethanol (110 mL) at room temperature under nitrogen and stir the mixture for 12 hours. Remove the solvent under reduced pressure, dissolve the residue in ethyl acetate (200 mL), wash with saturated NaHCO3 (200 mL) and brine (200 mL) solutions, and dry over sodium sulfate. Remove the solvent under reduced pressure to provide 8-amino-8-(benzoylhydrazono)octanoic acid ethyl ester (8.3 g, 64%).

1. customRemove the solvent under reduced pressure
2. dissolutiondissolve the residue in ethyl acetate (200 mL)
3. washwash with saturated NaHCO3 (200 mL) and brine (200 mL) solutions
4. dry with materialdry over sodium sulfate
5. customRemove the solvent under reduced pressure