反应详情

温度

0 °C

To a stirred solution of DMF (30 mL) was added POCl3 (10.65 mL, 116 mmol) over 30 minutes at 0° C. The mixture was then stirred at 0° C. for 30 minutes and added 4 (11.75 g, 33.2 mmol) in DMF (120 mL). The mixture was stirred at room temperature for six days and the poured into ice-water. The product mixture was extracted with dichloromethane and the organic layer washed with water, aqueous sodium bicarbonate and brine, dried over sodium sulfate and concentrated to afford 13.58 g of 4-(dibenzylamino)-6-methoxy-1-naphthaldehyde (5) which was used in next step without further purification.

1. stirringThe mixture was stirred at room temperature for six days
2. extractionThe product mixture was extracted with dichloromethane
3. washthe organic layer washed with water, aqueous sodium bicarbonate and brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated