反应详情

温度

3 °C

1-ethoxycarbonyl-4-hydroxypiperidine (30.3 g) and triethylamine (23 g) were dissolved in ethyl acetate (182 mL) and the obtained mixture was cooled to 3° C. Methanesulfonyl chloride (22.05 g) was added thereto under stirring while taking caution such that the temperature did not exceed 20° C., and the mixture was continuously stirred under ice cooling for 1 hour. The obtained reaction mixture was washed with water (90 mL×3). The organic layer was isolated and concentrated to obtain a target compound as a light yellow oily substance. The yield amount was 43.09 g (98%).

1. customdid not exceed 20° C.
2. stirringthe mixture was continuously stirred under ice cooling for 1 hour
3. customThe obtained reaction mixture
4. washwas washed with water (90 mL×3)
5. customThe organic layer was isolated
6. concentrationconcentrated
7. customto obtain a target compound as a light yellow oily substance