反应详情

1-ethoxycarbonyl-4-mesyloxypiperidine (13.6 g), trifluoromethoxyphenol (4.0 g), tetrabutylammonium chloride (1.2 g) and potassium carbonate (7.72 g) were suspended in water (20 mL) and the suspension was refluxed for 3 hours. The reaction solution was cooled to room temperature, and then the reaction product was extracted with toluene (24 mL). The extract was washed with water (20 mL×2), and then the solvent was concentrated under reduced pressure to obtain a target compound as a light yellow oily substance. The yield amount was 12.03 g (%). The obtained target compound was used, for the subsequent reaction without being purified.

1. temperaturethe suspension was refluxed for 3 hours
2. extractionthe reaction product was extracted with toluene (24 mL)
3. washThe extract was washed with water (20 mL×2)
4. concentrationthe solvent was concentrated under reduced pressure
5. customto obtain a target compound as a light yellow oily substance
6. customThe obtained target compound was used, for the subsequent reaction
7. customwithout being purified