1-Butanol → Butyl 3-phenylpropanoate

HRID 1039794Notes

Reaction equation

HRID 1039794 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:13](O)[CH2:14][CH2:15]C.C(OC(C)C)(C)C>[Zn]>[C:1]1([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 2631-ButanolHCID 7643Methyl 3-phenylpropionateHCID 7914Diisopropyl Ether

Product 1

HCID 568855Butyl 3-phenylpropanoate

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Under a nitrogen atmosphere, a mixture of methyl 3-phenylpropionate (3.0 mmol), n-butanol (3.6 mmol), the zinc cluster obtained in the above-described Example 1 (0.0375 mmol), and diisopropyl ether (5.0 ml) was refluxed for 18 hours. As a result, butyl 3-phenylpropionate was obtained quantitatively.

Workup

  1. temperaturewas refluxed for 18 hours

Sources & evidence

ORD record
ord-7525cde55b944bc0a61ffa482034f1f9
Source dataset
uspto-grants-2013_10
Patent number
US08552204B2

Reaction notes

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