反应详情

温度

50 °C

A mixture of 2,5-dimethyl-4-iodoaniline (6.44 g, 26.1 mmol), benzyl bromide (11.50 g, 67.24 mmol) and potassium carbonate (8.20 g, 59.3 mmol) in EtOH (100 mL) was stirred at 50° C. for 12 h. The reaction mixture was then concentrated under reduced pressure. The residue (a purple solid) was mixed with DCM and this mixture was filtered using vacuum. The filtrate was purified by silica gel flash chromatography (0-5% MeOH in DCM) to give the title compound (9.35 g, 83% yield) as an oil.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. additionThe residue (a purple solid) was mixed with DCM
3. filtrationthis mixture was filtered
4. customThe filtrate was purified by silica gel flash chromatography (0-5% MeOH in DCM)