Hydrochloric Acid → HCID 178516168, compound

HRID 1040411Notes

Reaction equation

HRID 1040411 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([C:13]2[CH:17]=[C:16]([OH:18])[NH:15][N:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[NH:8]1[CH2:12][CH2:11][C@@H:10]([C:13]2[CH:17]=[C:16]([OH:18])[NH:15][N:14]=2)[CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178452025HCID 178452025, compound

Product 1

HCID 178516168HCID 178516168, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (R)-3-(5-hydroxy-1H-pyrazol-3-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (44 mg, 0.17 mmol) in CH2Cl2 (1 mL) was added HCl in dioxane (0.2 mL, 4.0 M). The reaction mixture was stirred for 48 h. Solvent was removed at reduced pressure to afford crude (R)-5-pyrrolidin-3-yl-2H-pyrazol-3-ol as a white solid. The material was used without further purification.

Workup

  1. customSolvent was removed at reduced pressure

Sources & evidence

ORD record
ord-ef046d5360714124959bda8112f72b63
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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