Hydrochloric Acid → HCID 86657590, compound

HRID 1040446Notes

Reaction equation

HRID 1040446 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[C:10]1([NH2:13])[CH2:12][CH2:11]1.[ClH:14]>O1CCOCC1>[ClH:14].[ClH:14].[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[C:10]1([NH2:13])[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 584311601-Oxazolo[4,5-b]pyridin-2-ylcyclopropanamine

Product 1

HCID 86657590HCID 86657590, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The Boc-protected 1-(1-oxazolo[4,5-b]pyridin-2-yl-cyclopropylamine (0.044 g, 0.160 mmol) was dissolved in 1,4-dioxane (0.5 mL) and to this solution was added 4N HCl in dioxane (2.50 mL, 10.9 mmol). The solution was stirred for 2 h. A ppt formed and the volatiles were removed in vacuo to afford 1-(1-oxazolo[4,5-b]pyridin-2-yl-cyclopropylamine dihydrochloride as a tan solid (0.023 g, 69%).

Workup

  1. customA ppt formed
  2. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-13382f0f4d104fc0af798953b8b1f5c6
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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