Hydrochloric Acid → HCID 58431097, compound

HRID 1040468Notes

Reaction equation

HRID 1040468 reaction equation
C(OC(=O)[NH:7][CH:8]([C:11]1[N:16]=[C:15]2[NH:17][CH:18]=[CH:19][C:14]2=[CH:13][CH:12]=1)[CH2:9][CH3:10])(C)(C)C.Cl>O1CCOCC1>[NH:17]1[C:15]2=[N:16][C:11]([CH:8]([NH2:7])[CH2:9][CH3:10])=[CH:12][CH:13]=[C:14]2[CH:19]=[CH:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58430993HCID 58430993, compound

Product 1

HCID 58431097HCID 58431097, compoundYield 133.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of [1-(1H-Pyrrolo[2,3-b]pyridin-6-yl)-propyl]-carbamic acid tert-butyl ester (230 mg, 0.84 mmol) in dioxane (2 mL) was added 4N HCl in dioxane (500 uL, 2.00 mmol). The reaction was stirred at room temperature for 1 h. Solvents were removed and the resulting brown oil was suspended in Toluene (3 mL×2). Removal of solvents to dryness affords 197 mg of the title compound 1-(1H-Pyrrolo[2,3-b]pyridin-6-yl)-propylamine as a HCl salt, m/z 176.40 [M+1]+.

Workup

  1. customSolvents were removed
  2. customRemoval of solvents to dryness

Sources & evidence

ORD record
ord-b7750e5bc8b84387bb0351afdd214bec
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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