Hydrochloric Acid → HCID 67391711, compound

HRID 1040533Notes

Reaction equation

HRID 1040533 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:10](=[O:21])[NH:11][C:12]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:14][CH2:13]1)[CH3:9])(C)(C)C.[ClH:23].O1CCOCC1>C(Cl)Cl>[ClH:23].[ClH:23].[NH2:7][C@@H:8]([CH3:9])[C:10]([NH:11][C:12]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:14][CH2:13]1)=[O:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67390883HCID 67390883, compound

Product 1

HCID 67391711HCID 67391711, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [(S)-1-(1-pyridin-2-yl-cyclopropylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (120 mg, 0.39 mmol) in CH2Cl2 (5 mL) was added 4M HCl in dioxane (0.98 mL, 3.9 mmol). The solution stirred for 4 hours then was concentrated in vacuo to afford crude (S)-2-amino-N-(1-pyridin-2-yl-cyclopropyl)-propionamide dihydrochloride (100 mg, 0.36 mmol).

Workup

  1. concentrationthen was concentrated in vacuo

Sources & evidence

ORD record
ord-36a06621437345abb84ed1ce90c7548f
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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