Potassium Carbonate → HCID 86633877, compound
Reaction equation
Cl.[NH2:2][C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[OH:9].C(=O)([O-])[O-].[K+].[K+].[Cl:16][C:17]1[N:22]=[C:21](Cl)[C:20]([Cl:24])=[CH:19][N:18]=1>O1CCCC1>[Cl:16][C:17]1[N:22]=[C:21]([NH:2][C@@H:3]2[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]2[OH:9])[C:20]([Cl:24])=[CH:19][N:18]=1Participants
Procedure
Tetrahydrofuran (100 mL) was added to racemic trans-2-amino-cyclohexanol hydrochloride (4.28 g, 28.2 mmol) and potassium carbonate (12.1 g, 88 mmol). The mixture was cooled at 0° C. before 2,4,5-trichloropyrimidine (2 mL, 17.4 mmol) was added. After 3 hours, the mixture was partitioned between water and ethyl acetate, the aq. layer was extracted and the combined extracts were dried and conc. in vacuo. The crude product was taken up in ethyl acetate and washed with 10% w/v citric acid, then with sodium bicarbonate, dried over sodium sulfate and conc. in vacuo to give rel-(1R,2R)-2-(2,5-dichloro-pyrimidin-4-ylamino)-cyclohexanol (2.27 g, 50%) as a white solid. m.p.=139-142° C.; LCMS (m/e) 262 (M+1); 1H-NMR (DMSO-d6, 400 MHz) δ 8.12 (s, 1H), 7.45 (m, 1H), 68 (m, 1H), 3.81 (m, 1H), 3.55 (m, 1H), 1.92 (m, 1H), 1.81 (m, 1H), 1.67 (m, 2H), 1.41 (m, 1H), 1.26 (m, 3H).
Workup
- additionwas added
- customthe mixture was partitioned between water and ethyl acetate
- extractionthe aq. layer was extracted
- customthe combined extracts were dried and conc. in vacuo
- washwashed with 10% w/v citric acid
- dry with materialwith sodium bicarbonate, dried over sodium sulfate and conc. in vacuo
Sources & evidence
- ORD record
- ord-3f887703ddcc4c4bae61d80e50c98bba
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552186B2
Reaction notes
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