反应详情

To a solution of 7-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one solid (566.6 mg, 2.75 mmol) in DMF (5 mL) was added NaH (200 mg, 60% dispersion in mineral oil, 5.0 mmol). After stirring for 15 min, 1-bromo-3-methoxy-propane (764 mg, 5.5 mmol) was added and the mixture stirred at room temperature for 1 hour prior to quenching with 10% aqueous NH4Cl solution. Solvent was removed by rotary evaporation and the residue extracted into EtOAc, washed with water (2×), brine and dried by passing through a plug of MgSO4. The resulting filtrate was evaporated onto Florisil and purified by chromatography (silica gel, DCM→15% EtOAc/DCM gradient). The appropriate fractions were combined and evaporated to afford 1-(2-methoxy-ethyl)-7-nitro-1,3,4,5-tetrahydro-benzo[b]azepin-2-one as an oil that was carried onto the next step.

1. stirringthe mixture stirred at room temperature for 1 hour
2. customto quenching with 10% aqueous NH4Cl solution
3. customSolvent was removed by rotary evaporation
4. extractionthe residue extracted into EtOAc
5. washwashed with water (2×), brine
6. customdried
7. customThe resulting filtrate was evaporated onto Florisil
8. custompurified by chromatography (silica gel, DCM→15% EtOAc/DCM gradient)
9. customevaporated