1-Bromo-3-chloropropane → 3-(3-Chloro-propyl)-8-methoxy-1,3-dihydro-benzo[d]azepin-2-one

HRID 1041244Notes

Reaction equation

HRID 1041244 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:12]=[CH:11][NH:10][C:9](=[O:13])[CH2:8][C:7]=2[CH:14]=1.Br[CH2:16][CH2:17][CH2:18][Cl:19]>>[Cl:19][CH2:18][CH2:17][CH2:16][N:10]1[CH:11]=[CH:12][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:14][C:7]=2[CH2:8][C:9]1=[O:13]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 42200938-methoxy-2,3-dihydro-1H-3-benzazepin-2-one

Product 1

HCID 204337693-(3-Chloro-propyl)-8-methoxy-1,3-dihydro-benzo[d]azepin-2-one

Procedure

3-(3-Chloro-propyl)-8-methoxy-1,3-dihydro-benzo[d]azepin-2-one was prepared from 8-methoxy-1,3-dihydro-benzo[d]azepin-2-one and 1-bromo-3-chloropropane in an analogous manner to Example 251a. Product isolated as a brown solid (5.87 g, 84%). LC/MS (ESI+) 266 (M+H).

Sources & evidence

ORD record
ord-e226a35715294fb4bf986aa71dec2b69
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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