Trifluoroacetic acid → HCID 86624963, compound

HRID 1041861Notes

Reaction equation

HRID 1041861 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([O-:6])(=[O:5])=[O:4].[F:9][C:10]1[CH:11]=[C:12]([N+:20]([CH3:23])([CH3:22])[CH3:21])[CH:13]=[CH:14][C:15]=1[C:16]([O:18]C)=[O:17].FC(F)(F)C(O)=O>O>[F:1][C:2]([F:8])([F:7])[S:3]([O-:6])(=[O:5])=[O:4].[C:16]([C:15]1[CH:14]=[CH:13][C:12]([N+:20]([CH3:22])([CH3:21])[CH3:23])=[CH:11][C:10]=1[F:9])([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86624961HCID 86624961, compound

Product 1

HCID 86624963HCID 86624963, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2.50 g (6.92 mmol) 4b, 60 ml dest. water and 60 ml trifluoroacetic acid was refluxed for 2 days. The reaction mixture was evaporated, dried by use of oil pump vacuum over night and treated with diethyl ether. The resulting solid was filtered, washed extensively with diethyl ether and dried by oil pump vacuum. The solid crude product 4c was obtained in 100% yield (2.40 g; 6.92 mmol) and crude compound 4c was used for the next step without purification.

Workup

  1. customThe reaction mixture was evaporated
  2. customdried by use of oil pump vacuum over night
  3. additiontreated with diethyl ether
  4. filtrationThe resulting solid was filtered
  5. washwashed extensively with diethyl ether
  6. customdried by oil pump vacuum

Sources & evidence

ORD record
ord-5903b21d5a604f99ad7d3c8fd440e032
Source dataset
uspto-grants-2013_10
Patent number
US08557776B2

Reaction notes

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