Dichloromethane → HCID 178511701, compound

HRID 1041906Notes

Reaction equation

HRID 1041906 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:31][CH2:32][N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)[CH:25]=4)=[N:22][N:23]=3)[CH:20]=2)[CH2:10][CH2:9]1)(C)(C)C.C(Cl)Cl.[C:43]([OH:49])([C:45]([F:48])([F:47])[F:46])=[O:44]>>[F:46][C:45]([F:48])([F:47])[C:43]([OH:49])=[O:44].[N:33]1([CH2:32][CH2:31][O:30][C:26]2[CH:25]=[C:24]([C:21]3[N:19]4[CH:20]=[C:15]([O:14][C@H:11]5[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]5)[CH:16]=[CH:17][C:18]4=[N:23][N:22]=3)[CH:29]=[CH:28][CH:27]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178454064HCID 178454064, compound

Product 1

HCID 178511701HCID 178511701, compound

Procedure

A solution of Example 14 step a (196 mg, 0.178 mmol) in TFA (2 mL) and DCM (10 mL) was stirred at RT for 0.5 H, then concentrated in vacuo to give the title compound (quantitative yield). LCMS (Method 2): Rt 0.38 min, m/z 438 [M-CF3CO2+].

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c14e57496a90465f83ed0b5bf13ebb0f
Source dataset
uspto-grants-2013_10
Patent number
US08557797B2

Reaction notes

Loading…