反应详情

2-Bromoethyl methyl ether (85 μl) is added to a mixture of 4-(β-D-glucopyranos-1-yl)-2-(4-hydroxybenzyl)-benzonitrile (0.30 g) and cesium carbonate (0.39 g) in 3 mL of dimethylformamide. The mixture is stirred at 80° C. for 16 h, before water and brine are added. The resulting mixture is extracted with ethyl acetate, the combined extracts are dried over sodium sulphate and the solvent is removed under reduced pressure. The residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1).

1. additionare added
2. extractionThe resulting mixture is extracted with ethyl acetate
3. dry with materialthe combined extracts are dried over sodium sulphate
4. customthe solvent is removed under reduced pressure
5. customThe residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0->5:1)