Hydrochloric Acid → HCID 66764225, compound

HRID 1042013Notes

Reaction equation

HRID 1042013 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]23[CH2:15][N:12]([CH2:13][CH2:14]2)[CH2:11][CH2:10][CH2:9]3)=[CH:4][CH:3]=1.CS[C:18]1[S:22][C:21](B(O)O)=[CH:20][CH:19]=1.Cl.[CH3:27]C(O)C>>[ClH:1].[CH3:27][C:18]1[S:22][C:21]([C:2]2[N:7]=[N:6][C:5]([C:8]34[CH2:15][N:12]([CH2:13][CH2:14]3)[CH2:11][CH2:10][CH2:9]4)=[CH:4][CH:3]=2)=[CH:20][CH:19]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 2794627[5-(Methylsulfanyl)thiophen-2-yl]boronic acidHCID 57528563HCID 57528563, compound

Product 1

HCID 66764225HCID 66764225, compound

Procedure

This compound is obtained according to the method described in stage 1.6 of Example 1, using 5-(6-chloropyridazin-3-yl)-1-azabicyclo[3.2.1]octane, prepared according to stage 1.5 of Example 1, and 5-methylsulfanyl-2-thienylboronic acid. The hydrochloride thereof is prepared by treatment of the base with a solution of hydrochloric acid in propan-2-ol, and the crystals obtained are collected by filtration and dried under vacuum.

Workup

  1. customThis compound is obtained
  2. customprepared
  3. customthe crystals obtained
  4. filtrationare collected by filtration
  5. customdried under vacuum

Sources & evidence

ORD record
ord-8ac0d282cf13444a90b18265a4a89162
Source dataset
uspto-grants-2013_10
Patent number
US08557819B2

Reaction notes

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