1,3-Propanediol → HCID 178520875, compound

HRID 1042043Notes

Reaction equation

HRID 1042043 reaction equation
[Cl-].[Cl:2][C:3]1[C:12]2[C:7](=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:9]=[CH:10][CH:11]=2)[O+:6]=[C:5]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:4]=1.[CH2:25]([OH:29])[CH2:26][CH2:27][OH:28].C(N(CC)C(C)C)(C)C>>[Cl-:2].[OH:28][CH2:27][CH2:26][CH2:25][O:29][C:3]1[C:12]2[C:7](=[C:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:9]=[CH:10][CH:11]=2)[O+:6]=[C:5]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:4]=1

Participants

4

Reactant 3

HCID 104421,3-PropanediolHCID 81531DiisopropylethylamineHCID 178478242HCID 178478242, compound

Product 1

HCID 178520875HCID 178520875, compound

Conditions

Temperature
120 °C

Procedure

A 2 mL microwave vial was charged with a magnetic stirring bar, 4-chloro-2-morpholino-8-phenylchromenylium chloride (78) (50 mg, 138 μmol), 1,3-propanediol (1 mL), and N,N-diisopropylethylamine (48 μL, 276 μmol). The vial was sealed, and the reaction mixture was magnetically stirred and heated under microwave irradiation to 120° C. for 10 minutes in a microwave reactor to give 4-(3-hydroxypropoxy)-2-morpholino-8-phenylchromenylium chloride (79).

Workup

  1. additionA 2 mL microwave vial was charged with a magnetic stirring bar
  2. customThe vial was sealed

Sources & evidence

ORD record
ord-9cb682c4524543cebcb87c93de4297f8
Source dataset
uspto-grants-2013_10
Patent number
US08557807B2

Reaction notes

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