Trifluoroacetic acid → HCID 87132430, compound

HRID 1042076Notes

Reaction equation

HRID 1042076 reaction equation
O[C:2]([CH:6]1[CH2:9][CH:8]([CH2:10][C:11]([OH:13])=[O:12])[C:7]1([CH3:15])[CH3:14])([C:4]#[CH:5])[CH3:3].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:3]=[C:2]([CH:6]1[CH2:9][CH:8]([CH2:10][C:11]([OH:13])=[O:12])[C:7]1([CH3:15])[CH3:14])[C:4]#[CH:5]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 262808[3-(2-hydroxybut-3-yn-2-yl)-2,2-dimethylcyclobutyl]acetic acid

Product 1

HCID 87132430HCID 87132430, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of Example 29A (253 mg, 1.2 mmol) in 5 mL of CH2Cl2 was added triethylsilane (250 μL, 1.6 mmol), followed by trifluoroacetic acid (116 μL, 1.6 mmol). The resulting mixture was stirred at room temperature for over night. Volatile organics were removed in vacuuo and the residue was evaporated with toluene (2×10 mL). The resulting title compound was used without further purification.

Workup

  1. customVolatile organics were removed in vacuuo
  2. customthe residue was evaporated with toluene (2×10 mL)
  3. customThe resulting title compound was used without further purification

Sources & evidence

ORD record
ord-0ee9e8921fdf449da280b55f8a935412
Source dataset
uspto-grants-2013_10
Patent number
US08557828B2

Reaction notes

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