HCID 59072103, compound → HCID 66726181, compound

HRID 1042128Notes

Reaction equation

HRID 1042128 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)=[CH:7][N:6]=1)(=[O:4])=[O:3]>C(O)C.O1CCCC1.[C].[Pd]>[CH3:1][S:2]([C:5]1[N:6]=[CH:7][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)=[CH:9][CH:10]=1)(=[O:4])=[O:3]

Participants

5

Reactant 1

HCID 59072103HCID 59072103, compound

Product 1

HCID 66726181HCID 66726181, compoundYield 100.3%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(methylsulfonyl)-5-(4-nitrophenoxy)pyridine (9.88 g) in ethanol (150 mL) and tetrahydrofuran (150 mL) was added 10% palladium carbon (1 g), and the mixture was stirred under a hydrogen atmosphere for 15 hr. Palladium carbon was removed, and the residue was concentrated under reduced pressure to give the title compound (8.9 g, yield 100%) as a pale-yellow oil.

Workup

  1. customPalladium carbon was removed
  2. concentrationthe residue was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a67f945fb6ed492fbb3ff7da7a623ae6
Source dataset
uspto-grants-2013_10
Patent number
US08557805B2

Reaction notes

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