Potassium Carbonate → 3-(4-Fluoro-2-propoxy-phenyl)-acrylic acid methyl ester

HRID 1042478Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[OH:13].C([O-])([O-])=O.[K+].[K+].[I-].[CH3:22][CH2:23][CH3:24]>>[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[O:13][CH2:22][CH2:23][CH3:24]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 18513226Propane iodide

HCID 668576933-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester

Product 1

HCID 668556023-(4-Fluoro-2-propoxy-phenyl)-acrylic acid methyl esterYield 100%

Procedure

3-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester (110.5 mg) was reacted with K2CO3 (111 mg) and propane iodide (0.1 ml) at 80° C. overnight as described above to yield title compound (134 mg, 100%)

Sources & evidence

ORD record: ord-2a69f49c048a4c0eac0cc267ae1f206f
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08557872B2

Reaction notes

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