Aluminium lithium hydride → 2-Butoxy-4-trifluoromethyl-benzaldehyde

HRID 1042488Notes

Reaction equation

HRID 1042488 reaction equation
[CH2:1]([O:5][C:6]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:7]=1[C:8](N(OC)C)=[O:9])[CH2:2][CH2:3][CH3:4].[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOC(C)=O>[CH2:1]([O:5][C:6]1[CH:17]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:15]=[CH:14][C:7]=1[CH:8]=[O:9])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 866499672-butoxy-N-methoxy-N-methyl-4-trifluoromethyl-benzamide

Product 1

HCID 866499682-Butoxy-4-trifluoromethyl-benzaldehydeYield 63.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Butoxy-N-methoxy-N-methyl-4-trifluoromethyl-benzamide (825 mg) was reacted with 1 M LAH (31 ml) at −50° C. for 1 hour as described above to yield title compound (423 mg) after column chromatography (Hex/EtOAc=20/1).

Sources & evidence

ORD record
ord-b56e6dcf665648a0af35126d9c243e98
Source dataset
uspto-grants-2013_10
Patent number
US08557872B2

Reaction notes

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