2-Iodobutane → 3-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid methyl ester

HRID 1042494Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[OH:13].C([O-])([O-])=O.[K+].[K+].I[CH:22]([CH2:24][CH3:25])[CH3:23]>>[CH3:1][O:2][C:3](=[O:14])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=1[O:13][CH:22]([CH2:24][CH3:25])[CH3:23]

Participants

Reactant 3

HCID 105592-Iodobutane

HCID 11430Potassium Carbonate

HCID 668576933-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester

Product 1

HCID 668559553-(2-Sec-butoxy-4-fluoro-phenyl)-acrylic acid methyl ester

Procedure

3-(4-Fluoro-2-hydroxy-phenyl)-acrylic acid methyl ester (120 mg) was reacted with K2CO3 (165 mg) and 2-iodobutan (0.12 ml) at 100° C. for 3 hrs as described above to yield title compound (105 mg)

Sources & evidence

ORD record: ord-62fc0347c8804a7695243e6c1ae399e8
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08557872B2

Reaction notes

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