Lithium Hydroxide → HCID 66855446, compound

HRID 1042505Notes

Reaction equation

C1(C[O:8][C:9](=[O:28])[C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:11]=2[O:20][CH2:21][CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)CCCCC1.[Li+].[OH-]>>[CH:22]1([CH2:21][O:20][C:11]2[CH:12]=[C:13]([C:16]([F:17])([F:18])[F:19])[CH:14]=[CH:15][C:10]=2[C:9]([OH:28])=[O:8])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58111822HCID 58111822, compound

Product 1

HCID 66855446HCID 66855446, compoundYield 90%

Procedure

2-Cyclohexylmethoxy-4-trifluoromethyl-benzoic acid cyclohexylmethyl ester (528 mg, 1.33 mmol) was reacted with 1N LiOH (2.65 mg, 2.65 mmol) as described above to give 2-cyclohexylmethoxy-4-trifluoromethyl-benzoic acid (361 mg, 90%) after drying by vacuum.

Sources & evidence

ORD record: ord-84c251267afd4f3bb4848984b06d5daa
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08557872B2

Reaction notes

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