反应详情

温度

50 °C

A pyrex reaction tube was charged with Pd(PPh3)4 (200 mg, 173 μmol), 4-chloro-6-iodoquinoline (1.00 g, 3454 μmol), zinc cyanide (406 mg, 3454 μmol) and DMF. The tube was purged with argon, sealed, and the heterogeneous mixture was stirred at 50° C. for 17 h. The mixture was poured into water and the resulting solids were filtered, washed with water, and dried. The crude material was purified by silica gel chromatography, 0-5% MeOH/DCM to provide 4-chloroquinoline-6-carbonitrile as a white solid. MS: [M+H]=189.

1. customThe tube was purged with argon
2. customsealed
3. additionThe mixture was poured into water
4. filtrationthe resulting solids were filtered
5. washwashed with water
6. customdried
7. customThe crude material was purified by silica gel chromatography, 0-5% MeOH/DCM