反应详情

温度

90 °C

1-methyl-1H-benzo[d]imidazol-5-ol (296 mg), methyl 4-bromo-2-fluorobenzoate (311 mg) and potassium carbonate (553 mg) were combined in dimethylsulfoxide and heated to 90° C. overnight. The reaction mixture was diluted with ethyl acetate and washed thoroughly with water and with brine, dried over MgSO4, filtered and concentrated.

1. washwashed thoroughly with water and with brine
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated