Piperazine → HCID 67226485, compound

HRID 1043190Notes

Reaction equation

HRID 1043190 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:10][C:11]2[CH:20]=[C:19](F)[CH:18]=[CH:17][C:12]=2[C:13]([O:15][CH3:16])=[O:14])[CH:5]=[N:6][C:7]=1[NH:8][CH3:9].[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CS(C)=O.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([O:10][C:11]2[CH:20]=[C:19]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[CH:18]=[CH:17][C:12]=2[C:13]([O:15][CH3:16])=[O:14])[CH:5]=[N:6][C:7]=1[NH:8][CH3:9]

Participants

5

Reactant 2

HCID 4837PiperazineHCID 67228421HCID 67228421, compound

Product 1

HCID 67226485HCID 67226485, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of EXAMPLE 377E (0.230 g) and piperazine (0.255 g) in dimethylsulfoxide (3 mL) was heated to 85° C. for 1 hour. The reaction was cooled and diluted with ethyl acetate (75 mL). The organic layer was washed with water (3×50 mL) and brine (50 mL), dried over magnesium sulfate, filtered, and concentrated to give the title compound.

Workup

  1. temperatureThe reaction was cooled
  2. washThe organic layer was washed with water (3×50 mL) and brine (50 mL)
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-fb82cb62917546cc8ccf1a428bc54b8d
Source dataset
uspto-grants-2013_10
Patent number
US08557983B2

Reaction notes

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