HCID 86647915, compound → HCID 67126817, compound

HRID 1043242Notes

Reaction equation

HRID 1043242 reaction equation
[CH2:1]([C:3]1([OH:21])[CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OCC2C=CC=CC=2)[CH2:5][CH2:4]1)[CH3:2]>O1CCCC1.[Pd]>[NH2:10][CH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH2:1][CH3:2])([OH:21])[CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 86647915HCID 86647915, compound

Product 1

HCID 67126817HCID 67126817, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of EXAMPLE 447A (500 mg) and 10% Pd/C (100 mg) in tetrahydrofuran (15 mL) was stirred under H2 for 3 hours. The insoluble material was removed by filtration, and the filtrate was concentrated to give the title compound.

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-b6f480f501ac4e0caae2538eb72a6a32
Source dataset
uspto-grants-2013_10
Patent number
US08557983B2

Reaction notes

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