Hydrazine hydrate (1:1) → HCID 66886874, compound

HRID 1043468Notes

Reaction equation

HRID 1043468 reaction equation
[F:1][CH:2]([F:9])[C:3](=[O:8])[CH2:4][C:5](=O)[CH3:6].O.[NH2:11][NH2:12]>O1CCCC1>[F:1][CH:2]([F:9])[C:3]1([OH:8])[NH:12][N:11]=[C:5]([CH3:6])[CH2:4]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27784881,1-Difluoropentane-2,4-dione

Product 1

HCID 66886874HCID 66886874, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
25 °C

Procedure

To a solution of 1,1-difluoropentane-2,4-dione (2.5 g, 0.018 mol) in tetrahydrofuran (32 mL) was added hydrazine hydrate (0.98 mL, 0.020 mol) in tetrahydrofuran (32 mL) dropwise. The reaction was stirred at 25° C. for 16 hours and then concentrated in vacuo. The residue was used in the next reaction without further purification. 1H NMR (CDCl3): δ 5.68-5.96 (t, 1H), 5.50-5.80 (br s, 1H), 2.98 (dd, 1H), 2.68 (dd, 1H), 2.01 (s, 3H).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was used in the next reaction without further purification

Sources & evidence

ORD record
ord-f533184b2047423894e2ecc25d75d8cd
Source dataset
uspto-grants-2013_10
Patent number
US08563541B2

Reaction notes

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