Hydrochloric Acid → Triazabicyclodecene

HRID 1043750Notes

Reaction equation

HRID 1043750 reaction equation
[C:1](N)(N)=N.C(N)(N)=N.C(O)(O)=O.Cl.[CH2:14]([CH2:17][NH:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH2:15][NH2:16]>O>[N:18]12[CH2:19][CH2:20][CH2:21][NH:22][C:1]1=[N:16][CH2:15][CH2:14][CH2:17]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5942Bis(3-aminopropyl)amineHCID 11650Guanidine carbonate

Product 1

HCID 79873Triazabicyclodecene

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In still another specific exemplary embodiment, as shown in Scheme 3 and Example 2 below, a guanidine carbonate salt (1) is dissolved in water and reacted with hydrochloric acid, followed by addition of dipropylene triamine (2). The resulting solution is warmed to reflux and stirred for 4-6 hours to yield the chloride salt of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (4) in water, as shown below:

Workup

  1. temperatureThe resulting solution is warmed
  2. temperatureto reflux

Sources & evidence

ORD record
ord-a2bfc60a5b7543b285fc5d5beb514974
Source dataset
uspto-grants-2013_10
Patent number
US08563560B2

Reaction notes

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