Methyl iodide → HCID 57970751, compound

HRID 1044361Notes

Reaction equation

HRID 1044361 reaction equation
[H-].[Na+].[O:3]=[C:4]1[C@@:8]2([CH2:13][CH2:12][CH2:11][N:10]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:24])[O:22][CH3:23])=[CH:16][CH:15]=3)[CH2:9]2)[CH2:7][CH2:6][N:5]1[CH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.O1CCC[CH2:32]1.CI>>[CH3:32][N:20]([C:17]1[CH:18]=[CH:19][C:14]([N:10]2[CH2:11][CH2:12][CH2:13][C@@:8]3([C:4](=[O:3])[N:5]([CH:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[CH2:6][CH2:7]3)[CH2:9]2)=[CH:15][CH:16]=1)[C:21](=[O:24])[O:22][CH3:23]

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 57970790HCID 57970790, compound

Product 1

HCID 57970751HCID 57970751, compound

Procedure

Sodium hydride (1.6 mg, 0.000041 mol) was added to a solution of methyl {4-[(5S)-1-oxo-2-(tetrahydro-2H-pyran-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]phenyl}carbamate (8.0 mg, 0.000021 mol) in tetrahydrofuran (1.0 mL, 0.012 mol) at rt. After stirring for 5 min., methyl iodide (2.6 μL, 0.000041 mol) was added and the reaction mixture was stirred for 1 h at rt. The crude product was purified by prep-HPLC. LC-MS: 402.3 (M+H)+.

Workup

  1. stirringthe reaction mixture was stirred for 1 h at rt
  2. customThe crude product was purified by prep-HPLC

Sources & evidence

ORD record
ord-78413029dedf48baacd68740e0bc3267
Source dataset
uspto-grants-2013_10
Patent number
US08563570B2

Reaction notes

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